| Title |
Induced Neuronal Differentiation of SH-SY5Y Cell by Electrical Stimulation on the Graphene Electrode |
| Authors |
오홍기(Hong Gi Oh) ; 송광섭(Kwang Soup Song) |
| DOI |
https://doi.org/10.5573/ieie.2019.56.3.107 |
| Abstract |
Bioelectrodes for treating neurological diseases are required to have high electrical conductivity capable of detecting or effectively stimulating signals, and biocompatibility that does not cause toxicity when inserted into the body. In this paper, neuronal differentiation by electrical stimulation was induced by using graphene electrode. The graphene electrode has high electrical conductivity and excellent biocompatibility. To evaluate the degree of differentiation induced by the electrical stimulus, the length of the neurite was analyzed using software from the fluorescence image. The average length of differentiated neurons in the graphene electrode with electrical stimulation increased by 140.8% compared to the graphene electrode without electrical stimulation. And the neuronal differentiation was evaluated on the oxygenated graphene electrode. The average neurite length increased by 110.5% on the oxygenated graphene electrode compared to the pristine graphene electrode and increased 161.2% in the oxygenated graphene electrode with electrical stimulation. |