| Title |
Theoretical Analysis on the Effect of Stimulation Duration on Photothermal Neural Activation using Hodgkin-Huxley Model |
| Authors |
김명규(Myeong-Gyu Kim) ; 박성윤(Sung-Yun Park) ; 엄경식(Kyungsik Eom) |
| DOI |
https://doi.org/10.5573/ieie.2022.59.1.74 |
| Keywords |
Photothermal neural stimulation; Infrared neural stimulation; Gold nanoparticle; Hodgkin-Huxley model; Neural modeling |
| Abstract |
Due to the non-invasive nature of light and the ability to focus light energy in a local area, a neuromodulation technique using light has been spotlighted. Among them, a photothermal neuromodulation technique consisting of an infrared neural stimulation (INS) and a gold nanoparticles assisted near-infrared nerve stimulation (AuNP-NINS) employs instantaneous heat generated vicinity to the target for neural activation. Recently, many experimental and theoretical verification studies have been published, however, they lack biophysical analysis of the stimulation principles of the two techniques and theoretical considerations on the effect of light stimulation length. In this study, we employ the Hodgkin-Huxley(HH) model to electrically model nerves and theoretically compare and analyze the biophysical principles of the two stimulation techniques. In the case of the AuNP-NINS, the transient increase of temperature in response to the light stimulation is rapid and thereby the influence of the displacement current on the nerve stimulation is relatively greater than that of the INS. Moreover, the AuNP-NINS requires lower threshold temperature to elicit nerve activation compared to the INS. The shorter the stimulation duration, the greater the light intensity was observed, whereas the threshold temperature decreases thereby alleviating concerns of the possible nerve damage. This study can be used as a useful index for setting neuromodulation conditions for safe and effective photothermal neurostimulation in future clinical applications. |