| Title |
Modeling of TRPV4 Channel for Theoretical Analysis of Photothermal Neural Stimulation of Retinal Ganglion Cells |
| Authors |
이재욱(Jaewook Lee) ; 조성훈(Seonghoon Jo) ; 성경모(Kyung-Mo Sung) ; 엄경식(Kyungsik Eom) |
| DOI |
https://doi.org/10.5573/ieie.2022.59.10.111 |
| Keywords |
Photothermal neural stimulation; Gold nanoparticle; Hodgkin-Huxley model; TRPV4 channel; Retinal prosthesis |
| Abstract |
Retinistis pigmentosa and age-related macular degeneration are the representative neurological eye diseases that cause blindness. Among various treatments for visual restoration, retinal prosthesis is known to restore partial vision of these patients by modulating neuronal activities of intact retinal neurons. Recently, gold nanoparticle-mediated photothermal activation of retinal ganglion cell has been proposed and demonstrated its visual restoration in the experimental animals. However, the optimized stimulation parameters for safe and effective stimulation of retinal ganglion cells have not been performed. In this paper, we modeled a retinal ganglion cell containing six different ion channels including the temperature sensitive TRPV4 channel. Using Hodgkin-Huxley model we numerically analyzed the behavior of retinal ganglion cell upon photothermal stimulation combined with plasmonic gold nanoparticle. We found that TRPV4 channel current and capacitive current both synergistically increase the membrane potential to activate the retinal ganglion cell. The stimulation threholds were determined as 1.26 W/mm2 which leads to temperature elevation of 2.1 ℃. Theoretical modeling of photothermal neural activation of retinal ganglion cell opens up the possibilities for easy determination of optimal stimulation parameters for retinal prosthesis. |