| Title |
Development of the Analytical Method for Residual Pharmaceuticals in Raw Water Using Online Sample Preconcentration with High Resolution LC-ESI/Orbitrap MS |
| Authors |
황윤정 ( Yoo Jung Hwang ) ; 신상희 ( Sang Hee Shin ) ; 박종숙 ( Jong Suk Park ) |
| Keywords |
High resolution; Online sample pre-concentration; Orbitrap LC-ESI-MS; Residual pharmaceuticals |
| Abstract |
In this study, the analytical method for 27 residual pharmaceuticals in raw water was developed. Online sample preconcentration/extraction and analysis with high resolution Orbitrap mass spectrometry (LC-ESI/Orbitrap MS) were performed. The calibration curves showed good linearities (above r2 = 0.998) in the range of 5 ∼ 1,000 ng/L. The method detection limit and the limit of quantification were 1.1 ∼ 10.0 ng/L and 3.4 ∼ 31.7 ng/L, respectively. Recoveries of the target compounds were between 70.1% and 115.8% (except cefadroxil, cefradine, vancomycin, and iopromide (50.2 ∼ 67.0%)). The optimized analytical method can be useful to determine the residual pharmaceuticals in raw water. |