| Title |
A Study on the Behavior Change of Zebrafish For Toxicity Evaluation of Residual Psychoactive Medication in Wastewater Treatment Plant Effluent |
| Authors |
윤효직 ( Hyojik Yoon ) ; 김민재 ( Minjae Kim ) ; 김종락 ( Jongrack Kim ) ; 김성표 ( Sungpyo Kim ) |
| DOI |
https://doi.org/10.15681/KSWE.2019.35.6.574 |
| Keywords |
Cognitive function; Environmental flow; PPCP; Zebrafish |
| Abstract |
As interest in health issues increases, it is imperative to ensure good water quality from wastewater treatment plant effluent to preserve environmental health. In particular, currently there is a lack of water ecosystem risk assessment on pharmaceutical substances remaining in effluent. In this study, antidepressant escitalopram (ESC), antiepileptic carbamazepine (CBZ) and lead, which impact the behavior of aquatic organisms, were used to test their impact on the potential behavior of zebrafish. Zebrafish have been widely used in toxicological assessment studies due to the ease of handlinggenerically and genetically. It was possible to observe changes in the growth of organisms through monitoring the embryos’ cognitive and behavior assessment. In this study, the embryo lethal dose test showed that the lethal concentration of ESC and CBZ was at 10 ppb, which is below the water quality criterion (100 ppb), increased by 32.5 % and 40 %, respectively. In the cognitive test, it was found that the cognitive ability function decreased by 22 % and 17% for ESC(500 ppb) and CBZ(1,000 ppb) respectively relative to control. Based on these results, it is necessary to initiate efforts to remove these trace pollutants from sewage treatment facilities to protect the health of aquatic organisms. |