| Keywords |
Estrogen receptor polymorphism ; Bone strength ; Body composition ; Elderly women |
| Abstract |
Generally, it has been suggested that genetic factors regulate both bone mineral density (BMD) and development of osteoporosis. This study was designed to clarify an association of estrogen receptor (ER) polymorphism with bone strength, body composition and basal physical fitness in Korean elderly women. We determined the ER genotype using a polymerase chain reaction (PCR) with Pvu II restriction fragment length polymorphism (RFLP), in a DNA sample of 22 elderly women aged 75.3±6.4 yrs. The genetic subtype was classified by its digestion patterns e.g. PP, Pp, pp, and then bone strength and basal physical fitness were compared among genotype. For the genotype distribution, 18% (n=4) were PP genotype, 45% (n=10) were Pp genotype and 36% (n=8) were pp genotype, respectively. The broadband ultrasound attenuation (BUA, db/MHz) of PP, Pp and pp genotypes were 80.2±5.1, 96.1±9.5, 96.2±15.0, respectively. PP genotype was significantly lower compared to other genotypes (p<0.05). The body weight and % fat of PP genotype were significantly lower than Pp genotype (p<0.05). The Sit-up, indicating muscle endurance, of PP genotype was significantly higher compared to those of other genotype (p<0.05). These results suggest that ER genotype using Pvu II might be used as a predictor which may affect bone strength, body composition, and physical fitness in Korean elderly women. |