| Keywords |
Exercise type ; Downhill running ; Plasma ; Anti-inflammatory cytokines |
| Abstract |
The purpose of this study was to investigate the alteration of plasma anti-inflammatory cytokines, including interleukin-6 (IL-6), soluble TNF receptor (sTNFr), IL-10, and interleukin-1 receptor antagonist (IL-1ra), during different types of running exercise(level and downhill running). Seven healthy male college students completed two different exercise trials on separate occasions: (1) level treadmill running at 75% VO2max for 30 min; (2) downhill treadmill running (?12% gradient) at 75% VO2max for 30 min. Blood was sampled before, immediately after, and 1 h, 4 h, 24 h after exercise. Visual analog scale (VAS) score was obtained at the same time point. Plasma was analyzed for cytokines and creatine kinase (CK) activity. The plasma concentrations of IL-6 increased significantly (P<0.05) after exercise in both trials but there was a difference in pattern of change between trials. CK activity and VAS score increased significantly after the downhill running but not in level running trial. IL-10, as like IL-6, increased significantly (P<0.05 or P<0.01) after downhill running but not in level running. There was no significant alteration of sTNFr and IL-1ra in both running trials. In conclusion, there was a different pattern in response of exercise-induced anti-inflammatory cytokines such as IL-6 and IL-10 between running types (level and downhill). |