| Keywords |
Interleukin 6 receptor gene polymorphism ; Obesity ; Inflammatory factor ; Cardiorespiratory fitness |
| Abstract |
The goals of this study were to investigate the relation of interleukin-6 receptor gene polymorphism and inflammatory factors, obesity indices, cardiovascular fitness. A total of 103 middle-aged women, who met the IDF criterion for abdominal obesity with waist circumference (WC) of ≥80 cm, were invited to participate in the study. And then subjects were categorized into two groups by means of BMI and waist (obesity I, BMI<25 kg/m2 and waist ≥80 cm; obesity II, BMI>25 kg/m2 and waist ≥80 cm). Blood Samples were drawn from an anticubital vein into syringe the morning after an overnight fast and then those were measured fasting lipid profiles, inflammation factors, and gene polymorphism. There were measured waist, BMI, %body fat, VAT, SAT, and GXT test. In this study, IL-6R gene polymorphism of participant showed linkage equilibrium (x2=0.85, p=0.64). IL-6R gene polymorphism showed significantly difference at BMI and TG between obesity I and obesity II. In conclusion, IL6R gene polymorphism were significantly associated with BMI (OB I, p=0.021) and TG (OB I, p=0.011; OB II, p=0.009), but that was not associated with cardiorespiratory fitness and inflammatory factor. Therefore, future research seems to be need interpretation about how to read obesity and insulin resistance by increase systemic IL-6R. |