| Keywords |
Treadmill exercise ; TNF-α mRNA ; UCP-3 mRNA ; MDA ; Diabetic rat |
| Abstract |
The purpose of this study was to investigate the expression of the uncoupling protein-3 (UCP-3) mRNA on brown adipose tissue, tumor necrosis factor-a (TNF-α) mRNA on skeletal muscle, malondialdehyde (MDA) level on liver tissue in diabetic rats. Subjects were 24 diabetic rats. Experimental animals were randomly assigned to an exercise group (n=12) and non-exercise group (n=12). Moderate treadmill running (14~16 m/min on a 0% treadmill) applied for 30 minutes per session, 5 sessions per week, for 4 weeks. moderate treadmill exercise stimulus to diabetic experimental rats triggered significant group difference in the expression of UCP-3 mRNA on brown adipose tissue (p<.001) and TNF-α mRNA on skeletal muscle (p<.001). In spite of this kinds of group difference, there was no significant group difference in the level of MDA on liver tissue (p>.05). Therefore, this study suggests that the moderate exercise plays a critical role to regulate specific gene expression levels in adipose tissue and skeletal muscle of diabetic rats. |