| Keywords |
Hippocampus ; Oxidative stress ; Glucose tolerance ; C57BL/KS/J-db/db mice |
| Abstract |
The aim of the present study was to investigate the effect of exercise on oxidative stress, production of lipid peroxidation and glucose tolerance in C57BL/KS/J-db/db mice Hippocampus. Thirty male C57BL/KS/J-db/db mice (weighing 22-26 g) were divided into sedentary groups (CON; n = 10), low intensity exercise groups (LIEG; n = 10), and high intensity exercise groups (HIEG; n = 10) at the age of 6 weeks. LIEG composed of mices which ran on a treadmill at a speed of 10 m/min, 30 min/day, 5 days a week, for 8 weeks. HIEG composed of mices which ran a treadmill at a speed of 16 m/min, 30 min/day, 5 days a weeks, for 8 weeks. The exercise groups were adapted to the treadmill run for 5 days. After 8 weeks of treadmill exercise, plasma glucose and glucose tolerance test, SOD, CAT, GPx, MDA in the hippocampus were measured. After treadmill exercise, The SOD, GPx, MDA activities of hippocampus were significantly (p < 0.05) higher in both LIEG and HIEG when compared to Control. and than CAT activities was no significant difference among the groups. Plasma glucose levels was significantly (p < 0.05) lower in both LIEG and HIEG when compared to Control. As a result, we propose that chronic treadmill exercise do not cause oxidant stress in type 2 diabetic rat hippocampus. These results indicate that chronic exercise play a beneficial antioxidant role in reducing the lipid peroxidant enhanced by improvement of glucose tolerance in type 2 diabetic rat hippocampus. |