| Keywords |
Treadmill exercise ; MAO-B ; Cerebrum ; Antioxidant |
| Abstract |
The aim of the present study was to investigate the effects of treadmill exercise on MOA-B enzyme activities, Acetylcholine, Lipid peroxide content and memory ability in aging rat's cerebrum. male F344 male rats (weighing 565-585 g) were used in this study. The rats were divided into three groups (n = 8 in each group): the sedentary groups (Con; n = 8), low intensity exercise groups (LIEG; n = 8), and high intensity exercise groups (HIEG; n = 8). The rats in the LIEG was force to run on a motorized treadmill at a speed of 5-8 m/min, 30 min/day, 4 days a week, for 12 weeks. HIEG was forced to ran on motorized treadmill at a speed of 22-25 m/min, 30 min/day, 4 days a weeks, for 12 weeks. After 12 weeks of treadmill exercise, rats were tested on a step-throught passive avoidance task in order to evaluate the memory ability and than MOA-B enzyme activities, acetylcholine, lipid peroxide content in aging rat's cerebrum were measured. After 12 weeks treadmill exercise, The MOA-B activities and MDA levels of cerebrum were significantly (p < 0.05) lower in LIEG when compared to HIEG. The acetylcholin levels of cerebrum was significantly (p < 0.05) higher in both LIEG and HIEG when compared to CON. Memory ability was significantly (p < 0.05) increased in both LIEG and HIEG when compared to CON. Based on the present results, it is suggested that longterm treadmill exercise do not cause oxidant stress in aging rat's cerebrum. These results indicate that long-term low intensity exercise play a beneficial antioxidant role and memory in reducing the lipid peroxidant enhanced by improvement of MOA-B and acetylcholin activities in the aging rat's cerebrum. |