| Keywords |
Resistance training ; Diabetes ; GLUT4 ; MCT |
| Abstract |
Currently, resistance training is recommended as a behavioral intervention to enhance metabolic profile in diabetic patients. In the present study, we investigated the effect of resistance training on glucose transporter4(GLUT4) and monocarboxylate transporter(MCT) expression in skeletal muscle of rats with streptozotocin(STZ)-induced diabetes. Adult male Sprague-Dawley rats were randomly assigned to the following four groups: control group(n = 8), diabetic group(n = 8), diabetic and running group(n = 8), and diabetic and resistance group(n = 8). Diabetes was induced by a single injection of STZ(50 mg/kg body weight). Rats in the exercise groups were made to perform their respective exercise session four times per week for 12 weeks. Western blotting was performed to detect GLUT4 and MCT protein in skeletal muscle. Our data showed that GLUT4 and MCT protein levels was markedly decreased in the diabetic group when compared to the control group. However, both resistance and running training significantly increased GLUT4 and MCT protein in diabetic rats and the amount of these protein expression was similar between both trained groups. These results indicate that resistance training may be useful in alleviating metabolic impairment through the increase in glucose and lactate uptake in diabetic skeletal muscle. |