| Keywords |
Exercise ; Ghrelin ; Acylated ghrelin ; Obesity ; Adolescents |
| Abstract |
The purpose of this study is to determine the effect of combined exercise on ratio of acylated and unacylated ghrelin during a 12-week aerobic and resistant training program in untrained obese adolescent. Twenty 13-year-old boys were randomly assigned to one of two groups: a control group who performed no additional exercise and an exercise group who performed a combined exercise. The combined exercise program, consisting of aerobic exercise and resistance training, was performed by the experimental group under supervision for 12-week(three times a week) at 55-64% and 65-75% of maximum. At baseline and 12 weeks, body composition, lipid profile, total ghrelin and acylated ghrelin were measured. There were significant differences between the groups in the pattern of change of weight(p = 0.002), BMI(p = 0.04), body fat percentage(p = 0.03), body fat mass(p = 0.008), lean body mass percentage(p = 0.039), TC(p = 0.032), LDL-C(p = 0.039), total ghrelin(p = 0.004), unacylated ghrelin(p = 0.003), ratio of acylated ghrelin(p<0.001), and ratio of unacylated ghrelin(p < 0.001) levels during the 12-week study. These findings suggest that exercise ameliorate appetite and energy metabolism of obese adolescent through ratio of acylated ghrelin and unacylated ghrelin levels changing from 12-week combined exercise. |