| Keywords |
BDNF ; Hippocampus ; Cerebral cortex ; Cerebellum ; ELISA |
| Abstract |
This experiment was executed with four week Sprague-Dawley rats in order to examine an effect that swimming exercise had on brain derived neurotrophic factor(BDNF) protein expression in the brain of the adolescent rats. The control and exercise groups were classified into swimming 1 day(n=10), 3 days(n=10), and 7 days(n=10) groups. BDNF protein expression was observed and the results as following were gained in using ELISA(Enzyme -linked immunoAssay) after swimming exercise was practiced an hour a day. In the cerebral cortex the BDNF expression by swimming exercise was increased in 1 day, 3 days, and 7 days and the significant difference was observed statistically(p<0.001). In the cerebellum the BDNF expression of the exercise groups by swimming exercise was increased in 1 day, 3 days, and 7 days as compared with the control groups and the significant difference was observed(p<0.001). In all of cerebral cortex and cerebellum the BDNF expression was increased more in 7days than in 1day so statistical significance was found. It showed the tendency to be increased in 3 days as compared with 1 day, but statistical significance was not found. In the hippocampus the BDNF expression of the exercise groups by swimming exercise was increased in 1 day, 3 days, and 7 days as compared with the control groups so the significant difference was observed statistically. Also It was increased more in 3 and 7 days than in 1 day, and most in 7 days so statistical significance was found(p<0.001). In cerebral cortex, cerebellum and specially hippocampus the BDNF expression was increased conspicuously. These results show that increase of BDNF protein synthesis by swimming exercise is judged to help to being proliferation, differentiation and formation of the adolescent brain cell and is thought to be related to the improvement of learning and memory at second hand. |