| Keywords |
Treadmill exercise ; IL-6 ; CRP ; Adiponectin ; AMPKβ1 |
| Abstract |
This study determined the effects of treadmill exercise on inflammatory response makers and AMPKβ1 expression of sleletal muscle in diabetic rats. Male spraugue Dewley rats(n=18) were randomly divided into diabetic control groups(DCG, n=9) and diabetic ecercise groups(DEG, n=9). The rats in the exercise groups ran on a treadmill for 30 min/day, 5 times a week, over the course of 12 weeks. At the end of experiment, blood samples were taken and the concentrations of plasma glucose, insulin, lipid profile, IL-6, CRP, and adiponectin concentrations were determined. After eight weeks of experiment, the expression of AMPKβ1 in skeletal muscle tissues from rats were detected by SDS- PAGE method and Western blotting. Eight weeks of treadmill exercise significantly decreased(p<.01) serum levels of CRP, and IL-6 in diabetic exercise rats when compared with DCG animals, while adiponectin levels were significantly increased. and then, AMPKβ1 expression of soleus muscle were significantly increased(p<.01)in diabetic exercise rats when compared with DCG animals. In conclusion, treadmill exercise can reduce the serum levels of inflammatory factors in diabetic rat, and increase AMPKβ1 expression. |