| Keywords |
Haptoglobin polymorphism ; Iron metabolism ; Maximum exercise test |
| Abstract |
This study was conducted to analyze distribution of the haptoglobin protein polymorphism and serum iron metabolism of 40 male students. To this end, a maximum exercise test with 20 of 40 students with Hp21 and Hp22 phenotypes was conducted and their blood was taken 5 times, while in stable state, immediately after exercise, 30 minutes, 4 hours and 24 hours after exercise, to analyze the effect of maximum exercise on the change in iron metabolism. The results of this research are as follows. With respect to the distribution of haptoglobin polymorphism, Hp22 phenotype was found to be most frequently and there were significant correlation between iron metabolism related indicators by haptoglobin polymorphism and haptoglobin concentration(F=9.647, P<.001). The results of post-test suggested there is significant difference between Hp21 phenotype and Hp22 phenotype(Dunnett's T3 post hoc test, P<.001). The concentration of serum iron metabolism declined until 30 minutes immediately after maximum exercise and gradually increased to its original level. Furthermore an effect of haptoglobin polymorphism was analyzed. The results suggested the individuals with Hp21 phenotype showed higher concentration of serum iron and haptoglobin than the individuals with Hp22 phenotype. In summary, an effect of the haptoglobin polymorphism on serum iron concentration variables shows a constant pattern irrespective of the time of blood sampling after maximum exercise and the individuals with Hp21 phenotype show higher serum iron haptoglobin concentration than the individuals with Hp22 phenotype, indicating a better of effect of Hp21 phenotype in preventing iron loss by maximum exercise. Thus it is essential to take account of genetic factors when planning exercise programs demonstrating efficient iron metabolism. |