| Keywords |
High fat diet ; Exercise ; Endoplasmic reticulum stress ; Skeletal muscle |
| Abstract |
The purpose of this study was to identify the effects of high-fat diet and exercise training of endoplasmic reticulum (EF) stress in skeletal muscle. Thirty-two Sparague Dawley male rats were divided into a control group (CON, n = 8), a High fat diet group (HF, n = 8), a high fat diet and a low intensity exercise group (HFLEX, n = 8) and a high fat diet and a high intensity exercise group (HFHEX, n = 8). It was carried out for twelve weeks with treadmill exercise. As a result, changes in body weight and body fat, and the fat in the blood components due to changes in obesity and hyperlipidemia were able to determine the general pattern, and the effects of exercise to reduce body weight and body fat, and blood lipid profiles were improved. ER stress signaling factor, such as a Bip, ATF4 and CHOP expression was increased in type I muscle fibers, Stress adaptation to exercise training in type Ⅰ fibers compared with low-intensity exercise at high intensity exercise in Bip and ATF4 mRNA was expressed in a significantly more distinct. This results in skeletal muscle by exercise training ER stress could be adapted to support the theory, but later due to a variety of area-specific or muscle fiber types studies will have to be continued. |