| Keywords |
Diabetic rat ; Exercise ; Inflammatory markes ; TNF-α mRNA ; HOMA-IR |
| Abstract |
The purpose of this study was to investigate the effect of exercise on inflammatory makers in the streptozotocin(STZ)-induced diabetic rats. 7 week-old male SD rats were divided into diabetes group(DM; n=10), Lowexercise group(Low+Ex; n=10), Mid-exercise group(Mid+EX; n=10) and High-exercise group(High+Ex; n=10). In the exercised groups, the rats exercised treadmill for 30 min/day, 4 days/week for 8 weeks. Data analysis was done by using SPSS(Ver.18.0) and one-way ANOVA. The results of this study are as follows: 8 weeks exercise significantly reduced pro-inflammatory(IL-1β, IL-6, TNF-α) and TNF-α mRNA while increasing the level of IL-10(p<.05). Also, in terms of HOMA-IR, the exercised groups made a more significant decrease than the DM group(p<.05). In conclusion, regular mid-intensive exercise decreases the activity of pro-inflammatory factors related to obesity and diabetes, and the exercise is considered a helpful way to improve anti-inflammatory factors. |