| Keywords |
Chlorella ; Exercise ; Antioxidant enzyme ; Cognitive skills |
| Abstract |
The aim of this study is to explore the effects of combined treatment of chlorella intake and exercise training on antioxidant enzyme activity and cognitive funtion in brain of type 2 diabetic mice. Forty male C57BL/ KsJ-db/db, 5 weeks old, were used. Experimental groups were randomly divided into 4 groups : DM (diabetic control group, n=10), DM+Ex (diabetic exercise group, n=10), DM+Ch (daibetic chlorella intake group, n=10), and DM+Ch+Ex (diabetic chlorella intake+exercise group, n=10). In the exercised groups, the mice exercise treadmill for 30 min/day, 5 days/week (1-4 weeks, 10 m/min or 5-8 weeks, 12 m/min) for 8 weeks. Data analysis was done by computer using SPSS (Ver.18.0) and one-way ANOVA; the results of this study are as follows: the DM+Ex group and DM+Ch+Ex group showed a significant increase in SOD activity of antioxidant enzymes compared to the control group; DM+Ch+Ex group showed a significant increase in CAT, GPx activity of antioxidant enzymes compared to the control group; the DM+Ex group and DM+Ch+Ex group showed a significant decrease in HOMA-IR level compared to the control group; DM+Ch+Ex group showed a significant decrease of escape latency compared to the control group. In conclusion, treadmill exercise and chlorella intake was a effective method to improve antioxidant system. |