| Keywords |
Insulin resistance ; Sarcopenic obesity ; Obesity ; Older adults |
| Abstract |
The purpose of this study was to determine whether sarcopenic obesity was associated with impairment in insulin resistance and glucose homeostatis in older adults over 60 years of age. Data was analyzed from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2010) with 1595 subjects of 60 years or older. Participants completed questionnaires and a whole body dual energy x-ray absorptiometry (DXA) scan. Sarcopenia was defined as an appendicular skeletal muscle mass (ASM) divided by weight (%) of 2 SD below the sex-specific mean for young adults. Obesity was defined as percent body fat above 60th percentile of the study sample. Body composition was categorized into four categories: normal, sarcopenic non-obese, normal obese, and Sarcopenic-obese (SO). Outcomes were Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), glycosylated hemoglobin level (HbA1C), and prevalence of type 2 diabetes. Covariates were age and educational. The proportion of SO was higher in women than men (7.3% vs. 4.1%). Obesity without sarcopenia were significantly associated with increased HOMA-IR in both men and women (p<.05). HOMAIR of SO were significant higher than that of sarcopenia (p<.05). However, no significant group differences were observed in HbA1C ratio. In females, adjusted for age and education, obese without sarcopenia and sarcopenic obesity was significantly associated with the prevalence of pre-diabetes and diabetes. However, in male, no associations were observed between the prevalence of pre-diabetes and diabetes and body composition. These results indicate that not only obesity but also sarcopenic obesity should also be considered as an important risk factor for prediabetes and type II diabetes mellitus in older women. More study of intervention for SO is needed to control metabolic disease in older adults. |