| Keywords |
Detraining ; p-AMPK ; p-ACC ; Malonyl-CoA ; HOMA-IR |
| Abstract |
This study was investigated the effects of detraining on p-AMPK, p-ACC, and Malonyl-CoA expression of skeletal muscle and cardiac muscle in a streptozotocin (STZ)-induced diabetic rats. At 7 weeks of age, S.D rats (n=34) were induced diabetes by administering STZ. A STZ-induced rats were randomly assigned to a normal control (Con, n=12), diabetic exercise group (DM+E, n=12) and diabetic control group (DM+C, n=10). The rats were trained progressively on a treadmill, five days per weeks for eight weeks following treadmill running programs: moderateintensity (20m/min for 60mins). After detraining for eight weeks, blood and tissues of skeletal muscle and heart were harvested. Detraining for 8 weeks significantly reduced HOMA-IR in diabetes rat models. Exercise groups significantly increased p-ACC and p-AMPK protein levels, and Malonyl-CoA levels were significantly reduced in exercise groups. In conclusion, the effects of 8 weeks exercise training were reduced by detraining for 8 weeks. However, the benefits of 8 weeks exercise training were still preserved. |