| Keywords |
Sedentary ; Interrupting of prolonged sitting ; Standing ; Arterial stiffness ; Vascular function |
| Abstract |
To examine the effects of breaking up prolonged sitting on arterial stiffness, compared with prolonged sitting in adults. Twelve healthy adults (26.3±6.1yr) participated in three randomized trials. Subjects attended three separate visits to the laboratory to complete each of the trial conditions in a randomized order: 1) uninterrupted of prolonged sitting; 2) standing; 3) sitting interrupted by moderate intensity walking (10min bouts of moderate-intensity walking), separated by a minimum 7-day washout period. To eliminate any diet-induced variability in study outcomes, dietary intakes were strictly controlled starting from breakfast to lunch. blood sampling (triglyceride and glucose), brachial blood pressure were measured at baseline, 4 hour and 6 hour. Augmentation index ,carotid-femoral pulse wave velocity and femoral-distal pulse wave velocity were measured as indices of arterial stiffness. TG and glucose concentrations significantly increased 4hr and 6hr than baseline in tree groups in similar manner, but no significant interaction effects. In standing and interrupting sitting trial, there were a significant decrease in augmentation index from baseline to 4h and 6h (p<0.001). Femoral-distal pulse wave velocity significantly decreased in standing and interrupting of prolonged sitting trial compared with uninterrupted of prologned sitting trial at 4hr (p=0.021, p=0.041). These finding show that a standing and interrupted sitting by short 10min bouts of moderate-intensity walking decrease in femoral-distal pulse wave velocity, compared with prolonged witting. Therefore, standing and interrupted of prolonged sitting (light activity) may improve peripheral vascular function in healthy adults. |