| Keywords |
ACh ; AChE ; β-Amyloid ; Apolipoprotein ; Cognitive function ; Treadmill exercise |
| Abstract |
This study was investigated the effects of exercise on ACh, AChE, β-amyloid, apolipoprotein expression and cognitive functions in scopolamine-induced memory impairment rats. At 7 weeks of age, SD rats (N=40) were induced memory impairment by administering scopolamine. A scopolamine-induced rats were randomly assigned to a control (CON, n=10), scopolamine-control(SCO-CON, n=10), low-intensity exercise (SCO-LEX, n=10), high-intensity exercise (SCO-HEX, n=10). The rats were trained progressively on a treadmill, five days per weeks for eight weeks following treadmill running programs: low-intensity (1-4 weeks: 10 m/min for 30 mins, 5-8 weeks: 12m/min for 30mins) and high-intensity (1-4 weeks: 15 m/min for 30 mins, 5-8 weeks: 16m/min for 30 mins). Both exercise groups significantly reduced β-amyloid and ApoE protein levels. ACh levels were significantly increased in both exercise groups. Both exercise groups showed a significant decrease of escape latency compared with the control group. In conclusion, treadmill exercise for 8 weeks was effective method to improve cognitive function, regardless of exercise intensity. |