| Keywords |
Huntington's disease ; Treadmill exercise ; Depression ; Neurotransmitter |
| Abstract |
The aim of the present study was to investigate the effects of treadmill exercise on depression and neurotransmitter(5- HT, TPH) in the huntington's disease rat model. Male rats were divided into sham-operation group(n=10), sham-operation & tread- mill exercise group(n=10), huntington's disease group(n=10), and huntington's disease & treadmill exercise group(n=10) at the age of 6 weeks. The rat in treadmill exercise group was made to treadmill exercise(5days/week, 30min/day) for 2 weeks. In the present results, treadmill exercise enhanced depression and neurotransmitter. Huntington's disease & treadmill exercise group significantly enhanced depression-like behavior and 5-HT & TPH expression compared to the huntington's disease group(p<0.05). These results indicate that treadmill exercise is effective for the depression improvement and brain functions of huntington disease's rat model. |