| Keywords |
Type 2 diabetes ; Interval training ; GLUT-4 mRNA ; Inflammatory ; Cardiovascular diseases |
| Abstract |
This study was investigated the effect of interval training on GLUT-4 mRNA expression of skeletal muscle and serum cytokines(IL-6, MCP-1, IL-10) concentration in diabetes mice. At 5 weeks of age, 57BL/KsJ-db/db mice(N=30) were randomly divide into three groups(n=10 in each group): diabetes group(DM), diabetes+low intensity training group(DM+LEX) and diabetes+high intensity interval training group(DM+HIT). Both training groups, the mice exercised treadmill for 30 min/day, 3 days/week for 8 weeks(low intensity continuous exercise vs high intensity interval exercise). Data analysis was done by using SPSS(Ver.20.0) and one-way ANOVA. The results of this study were follows: The GLUT-4 mRNA expression of skeletal muscle was significantly increased in both training group compared with control group, there was no significant difference between each training group. Serum pro-inflammatory cytokines( IL-6, MCP-1) levels were significantly lower in exercise groups than control group, whereas anti-inflammatory cytokine(IL-10) level was higher than control group. These results showed that HIT intervention can improve insulin sensitivity and inflammatory cytokine on cardiovascular diseases related with type 2 diabetes. HIT may be a valuable addition to a health-enhancing exercise program. |