| Keywords |
Diabetes; Aerobic exercise; Hippocampus; 5-HT; BDNF |
| Abstract |
In the present study, the effects of aerobic exercise on spatial learning and memory ability, expression of cortisol in serum, serotonin(5-HT) and brain-derived neurotrophic factor (BDNF) in hippocampus of Streptozotocin (STZ)-induced diabetic rats (4wks). The experimental animals were divided into three groups (n=10 in each group): the normal control group (CON), the diabetes mellitus group (DM), the diabetes and exercise group (DM-Ex). Animals in the exercise group were submitted to daily exercise in the water pool during 4weeks. The spatial learning and memory capabilities were evaluated by Morris water maze of rats. Western blotting analysis for the expression of BDNF and 5-HT was performed. Here in this study, it had shown that cortisol concentration in blood of DM-Ex group was significantly increased than DM group(p<.05), and both serotonin and BDNF expression in the hippocampus of DM-Ex group was significantly increased than DM group(p<.05). The results of the present study indicate that aerobic exercise may facilitate recovery from the CNS complications associated with diabetes by inducing enhanced the morphological development of synapses in the hippocampus via the augmentation of 5-HT and BDNF expression in the hippocampus. |