| Keywords |
Stress; Depression; Running exercise; Peptide; Orexin |
| Abstract |
PURPOSE: This study is to investigate the effects of wheel running exercise on orexin peptide level in depression-induced animal model.
METHODS: All C57BL6/J mice were 7-8 weeks, and mice that performed the bottom 20% wheel running after pretraining were excluded. Restraint stress was treated 14 days 2 hours a day. Forced wheel exercise was executed for 1 hour at a moderate speed of 9m/min. To identify the anti-depressive effects of exercise and changes in peptide expression, random sampling classified control, control-exercise, stress and stress-exercise. In addition, control, stress and stress-SB334867 to identify changes in depressive behavior due to orexin peptide regulation RESULTS: The results suggest that wheel running exercise significantly decreased depressive symptoms in ST+EX group compared with ST group in Tail Suspension Test. In addition, the orexin level of ST group were increased in the hippocampus region and significantly decreased in the ST+EX group. Treatment with orexin receptor antagonist modulated depressive behaviors.
CONCLUSIONS: These results suggest that forced running wheel has positive effects on depressive phenotype, and play an important role for clinical strategy of depression by regulating orexin levels |