| Keywords |
Smoking habite; physical activity; inflammation; oxdiative stress; telomere length |
| Abstract |
This study was to investigate the effects of smoking habits and physical activity on telomere length in middle aged men. This study was conducted on 106 middle aged men. We examined smoking habites such as smoking period and amount per week, physical activity inflammation markers including c-reactive protein (CRP) and lactate dehycrogenase (LDH), oxidative stress marker (8-OHG), and telomere length. Waist circumference were significant difference between smoking and non-smoking groups (p<.05). Physical activity (PA) were not difference between smoking and non-smoking groups. LDH levels significant difference between smoking and non-smoking groups (p<.05).
High-intensity PA has shown a negative association with LDH levels (r=-.117, p<.05) and 8-OHdG (r=-.234, p<.05).
Moderate-intensity PA frequency has shown a negative association with 8-OHdG (r=-.223, p<.05). Telomere length has shown a negative association with smoking period (r=-.340, p<.05) and LDH levels (r=-.239, p<.01). These results suggested that smoking and PA affected inflammation and oxidative stress, but did not affect telomere because it was not clinically meaningful. Therefore, it is considered that further research is needed to analyze the chnages according to observation at various time points in the long period. |