| Keywords |
Blood lipid; Estrogen; High-intensity interval exercise; Ovariectomized; Renin-angiotensin system |
| Abstract |
In this study, we investigated the effects of high-intensity interval exercise on blood lipids and reninangiotensin system (RAS)-related factors in ovariectomized rats. The rats were categorized into a control group (CON, n=10), an ovariectomized group (OVA, n=10), and an ovariectomized+high-intensity exercise group (OVA+HIE, n=10).
High-intensity interval exercise was performed on a treadmill for 30 min per session, once a day for 12 weeks. Data was analysed using one-way analysis of variance (ANOVA). Compared with the other groups, the total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels were significantly reduced and the high-density lipoprotein cholesterol levels were significantly increased in the OVA+TE group after 12 weeks of high-intensity interval exercise.
Additionally, ACE1 and AT1R mRNA expression were significantly reduced in the OVA+TE group. However, no significant intergroup difference was observed in SERCA2a mRNA expression. These results highlight that 12-week high-intensity interval exercise produced a positive effect on blood lipids and RAS-related factors in ovariectomized rats. |