| Title |
An Experimental Study on the Freeze Drying Process for Poly γ Glutamic Acid |
| Authors |
Jisu Kang ; Yeon-Ho Sim ; Si-Ye Byun ; Young Soo Chang ; Byung Ha Kang |
| DOI |
http://dx.doi.org/10.6110/KJACR.2015.27.12.645 |
| Keywords |
진공 동결 건조 ; 바이오 소재 ; 폴리감마글루탐산 ; 유리전이온도 Vacuum freeze drying ; Biomaterial ; Poly γ glutamic acid ; Glass transient temperature |
| Abstract |
This paper presents an experimental study on the freeze drying process for poly γ glutamic acid. The physical properties of poly γ glutamic acid are measured during the freeze-drying process. The moisture contents of poly γ glutamic acid according to the glass transient temperature are obtained by DSC (Differential Scanning Calorimetry) analysis. The end point of primary drying for the poly γ glutamic acid with a thickness of 3 mm is obtained by measuring the thickness of the dried layer, the amount of moisture evaporation, the moisture content, and the pressure in the drying vacuum chamber during the freeze-drying process. By considering the variation in the glass transient temperature with respect to the moisture content of the material, a control schedule for the heating plate temperature is suggested during the secondary drying process. |