| Title |
Application of Blue Laser Light for the Prevention of Stomal Stenosis |
| Authors |
Hanjae Pyo ; Hyeonsoo Kim ; Yeachan Lee ; Hyun Wook Kang |
| DOI |
http://doi.org/10.5207/JIEIE.2021.35.5.010 |
| Keywords |
Blue laser light; Heat transfer simulation; Laser application; Stomal stenosis |
| Abstract |
Stomal stenosis is a narrowing of stoma created by surgical incision and one of the most common complications that exist in patients after tracheostomy. Recently, blue laser light (405 nm) has been suggested as a non-surgical and noninvasive tool for preventing stenosis and scar through cell inactivation. However, the excessive photon energy may lead to irreversible damage in biological tissue due to excessive heat generation. Therefore, the purpose of this study is to numerically assess developments of temperature and thermal damage in a multi-layer tissue during 405 nm laser irradiation for the treatment of the stomal stenosis. The proposed simulation evaluates spatio-temporal changes of temperature induced by the 405 nm laser irradiation at 250, 500, and 1000 mW/cm2 for 300 s in the stomal stenosis model. The simulation results show that the irradiation of 250 mW/cm2 for 300 s increases the temperature of the stomal tissue up to 39.6 °C, which can induce a photochemical response with no or minimal thermal damage. Thus, the proposed bio-heat transfer simulation model can predict the extent of the laser-induced heat generation as well as thermal damage in the stomal tissue. Further studies will examine the identified irradiation condition in an animal model to evaluate a therapeutic capacity of the blue laser light for the prevention of the laryngeal stomal tissue. |